- PII
- 305188-690179-1
- DOI
- 10.7868/30179-1
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 44 / Issue number 6
- Pages
- 55-66
- Abstract
- A kinetic model of hemolysis of erythrocyte suspension under the action of the azo generator of peroxide radicals AAPH has been developed. Model is based on the assumption of cell hemolysis as a macroscopic consequence of the process of lipid peroxidation developing in the lipid region of the membrane, that lead to the accumulation of a certain molecular product, the critical concentration of which causes hemolysis. The kinetic component of the model is implemented as a solution to the direct problem of chemical kinetics with an obtainment of kinetic curves of formation of the supposed hemolysis factors. Due to the heterogeneity of the erythrocyte population, their morphological and other characteristics, including the response to the effect of the hemolytic factor, are statistically distributed. In this regard, the Gaussian normal distribution function was used as a mathematical basis for an accurate solution to the problem of the relationship between the degree of hemolysis and the concentration of the acting factor. This made it possible to describe the results of the hemolytic experiment with a good approximation.
- Keywords
- пероксидное окисление липидов гемолиз эритроцитов кинетическое моделирование нормальное распределение
- Date of publication
- 16.06.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 79
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