- PII
- S0207401X25030119-1
- DOI
- 10.31857/S0207401X25030119
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 44 / Issue number 3
- Pages
- 106-110
- Abstract
- Hybrid nanosystems based on magnetic iron oxide nanoparticles (IONPs) and human serum albumin (HSA), containing methylene blue (MB) as a model photosensitizer, have been synthesized. The resulting HSA@IONP nanosystems were characterized for size and composition using UV/visible spectrophotometry (particularly, using the Bradford method), dynamic light scattering, and electron magnetic resonance. A study of the dark and photoinduced cytotoxicity of MB, IONP, HSA@IONP, MB–IONP, MB–(HSA@IONP) on of human colon adenocarcinoma HCT116 cells was carried out. Under the experimental conditions, the difference between the dark and light-induced cytotoxicity of nanosystems on cells was significantly enhanced when the photosensitizer was immobilized on the surface of the carrier particles compared to free photosensitizer in equivalent concentrations.
- Keywords
- человеческий сывороточный альбумин наночастицы оксидов железа магнитные наночастицы фотодинамическая терапия гибридные наноразмерные системы метиленовый синий клеточная линия HCT116
- Date of publication
- 14.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 3
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