Deuterium Substitution and Charge Retention in Ions of Organic and Bioorganic Compounds. Part 2. Apamin Complex

Raznikova, M.O.

doi:10.7868/S3034612625090026

PII

S30346126S0207401X25090026-1

DOI

10.7868/S3034612625090026

Publication type

Article

Status

Published

Authors

M.O. Raznikova

Affiliation: Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences

Volume/ Edition

Volume 44 / Issue number 9

Pages

22-34

Abstract

The correspondence between the mass spectral components obtained by the separation of hydrogen/deuterium exchange (HDX) mass spectra of multiply charged ions of the apamin complex and specific structural forms of these ions has been confirmed. As in the case of apamin, the separation method is based on the best approximation of HDX mass spectra of multiply charged ions by a linear combination of several H/D/z peak distributions. These distributions assume independent replacement of exchangeable hydrogen atoms with deuterium and independent retention of z charge carriers. Based on the analysis of the complete set of HDX data for the apamin complex, including cases where the spectra of ions with certain charges were excluded, it is shown that the ion charge has no significant effect on the HDX processes of the major components (with contributions above 3%) during residual deuterium exchange in the apamin complex. In the presence of an ND gas flow, the observed changes for ions with different charges are minor and affect only the contributions of the major HDX mass spectral components, without taking into account the presence and localization of minor components with contributions below 10%.

Keywords

масс-спектрометрия дейтероводородный обмен электрораспыление растворов биомолекул масс-зарядовые распределения вероятности удерживания протонов и дейтронов центральная предельная теорема

Date of publication

15.09.2025

Year of publication

2025

Number of purchasers

Views

References

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GOST	Raznikova M. Deuterium Substitution and Charge Retention in Ions of Organic and Bioorganic Compounds. Part 2. Apamin Complex // Advances in Chemical Physics. – 2025. – V. 44. – Issue number 9 C. 22-34 . URL: https://chemphysras.ru/s30346126s0207401x25090026-1/?version_id=109187. DOI: 10.7868/S3034612625090026
MLA	Raznikova, M.O "Deuterium Substitution and Charge Retention in Ions of Organic and Bioorganic Compounds. Part 2. Apamin Complex." Advances in Chemical Physics. 44.9 (2025).:22-34. DOI: 10.7868/S3034612625090026
APA	Raznikova M. (2025). Deuterium Substitution and Charge Retention in Ions of Organic and Bioorganic Compounds. Part 2. Apamin Complex. Advances in Chemical Physics. vol. 44, no. 9, pp.22-34 DOI: 10.7868/S3034612625090026

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Deuterium Substitution and Charge Retention in Ions of Organic and Bioorganic Compounds. Part 2. Apamin Complex

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