- PII
- 10.31857/S0207401X24110058-1
- DOI
- 10.31857/S0207401X24110058
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 43 / Issue number 11
- Pages
- 39-46
- Abstract
- The article is devoted to the study of thermal denaturation of the plasminogen molecule during induced oxidation by hypochlorite in a concentration range (30, 62.5, 125 and 250 µM). By differential scanning calorimetry, it was determined that in the presence of an oxidizing agent, the enthalpy of denaturation of the plasminogen molecule decreases. This is most noticeable for the peak showing the melting of the K4-K5 domains. These results are consistent with previously obtained data on the oxidative modification of amino acid residues of plasminogen treated with different concentrations of hypochlorite using the HPLC-MS/MS method. Taken together, these data and the results of previous studies indicate that the structure of Glu-plasminogen is adapted to moderate HOCl-induced oxidation.
- Keywords
- плазмин(оген) окисление термическая денатурация дифференциальная сканирующая микрокалориметрия
- Date of publication
- 14.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 4
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