- PII
- 10.31857/S0207401X24110114-1
- DOI
- 10.31857/S0207401X24110114
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 43 / Issue number 11
- Pages
- 88-101
- Abstract
- In this work, the mechanisms of formation of the bisretinoid oxidation products in lipofuscin granules isolated from the retinal pigment epithelium cells of the human eye have been studied. The physico-chemical characteristics of the bisretinoid photooxidation products are described. The methods of IR spectroscopy, Raman spectroscopy, fluorescence spectroscopy, scanning confocal microscopy, time-of-flight mass spectrometry of secondary ions (TOF.SIMS) and HPLC were used for the study. The properties of the products of photooxidation and degradation of the fluorophore of lipofuscin granules, including synthetic N-retinylidene-N-retinylethanolamine (A2E), are described in detail. It has been shown that the products of oxidative degradation of lipofuscin granules are similar to the products of photooxidation of the main bisretinoid of lipofuscin granules – A2E. These data are important both for understanding the mechanisms of formation of cytotoxic products in lipofuscin granules and for establishing their chemical nature.
- Keywords
- бисретиноиды окислительная деградация флуорофоры липофусциновые гранулы ретинальный пигментный эпителий
- Date of publication
- 14.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 4
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